Quinone Pyrroloquinoline (PQQ) (72909-34-3)

March 11, 2019
SKU: 108-09-8
5.00 jade ti 5 da lori 1 onibara rating

Pyrroloquinoline quinone (PQQ), ti a tun pe ni methoxatin, jẹ cofactor redox. O wa ninu ile ati awọn ounjẹ bii kiwifruit, bi …… ..


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

Pyrroloquinoline quinone (PQQ) (72909-34-3) fidio

Awọn alaye Pyrroloquinoline quinone (PQQ) (72909-34-3) Awọn alaye ni pato

ọja orukọ Pungroloquinoline quinone (PQQ)
Orukọ Kemikali Coenzyme PQQ; Methoxatine; Quinone Pyrrolo-quinoline;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
molikula agbekalẹ C14H6N2O8
molikula iwuwo 330.21
Ibi Monoisotopic 330.012415 g / mol
Boliing Point 1018.6 ± 65.0 ° C (Asọtẹlẹ)
Itan filasi 569.8 ° C (1,057.6 ° F; 842.9 K)
iwuwo 1.963 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ Omi-pupa Alaga
Igbona ibi ipamọ 2-8 ° C
solubility Soluble ninu omi
ohun elo A ti royin PQQ lati ṣiṣẹ bi Vitamin ajile / cofactor omi ati bi antioxidant kan. O tun jẹ ipinnu fun lilo ninu awọn afikun ijẹẹmu, bii agbara, rirọpo ounjẹ, ati awọn ọpa odi ati be be lo.

ohun ti o jẹ Quinone Pyrroloquinoline(PQQ)?

Pyrroloquinoline quinone (PQQ), ti a tun pe ni methoxatin, jẹ cofactor redox. O wa ninu ile ati awọn ounjẹ bii kiwifruit, bi wara eniyan. Quinone Pyrroloquinoline jẹ pyrroloquinoline ti o ni awọn ẹgbẹ oxo ni awọn ipo 4- ati 5 ati awọn ẹgbẹ ọkọ oju opo ni awọn ipo 2-, 7- ati 9. O ni ipa kan bi Vitamin-tiotuka-omi ati cofactor. Ati, o jẹ olufihan ami kan fun awọn ibatan ti awọn ọlọjẹ ti o lowo ninu iyatọ ti awọn sẹẹli mammalian. Agbara atunlo giga ti PQQ le fun ni ipa elegbogi ni idaabobo lodi si neurodegeneration ati akàn. (Gẹgẹbi oluranlọwọ redox, Quinone Pyrroloquinoline jẹ idurosinsin pupọ ati pe o le kopa ninu awọn aati ọgọrun diẹ sii ju awọn antioxidants miiran lọ, bii ascorbic acid, quercetin, ati epicatechin.

Quinone ti Pyrroloquinoline jẹ biofactor aramada, ati pe a mọ ọ bi ọlẹ-inu enzymu ninu awọn kokoro arun. Awọn iwadii fihan pe quinone Pyrroloquinoline le ti wa ni igbagbogbo jakejado irọlẹ ti ibi ati itankalẹ. Gẹgẹbi ifosiwewe agbara ọgbin, o wa ninu idagba ti awọn ẹranko ati eniyan. Pungroloquinoline quinone ni a ṣe ijabọ lati kopa ninu ọpọlọpọ awọn iṣẹ ti ibi pẹlu awọn anfani iwalaaye ti o han gbangba (fun apẹẹrẹ, idagbasoke ọmọ tuntun ati iṣẹ ibisi) ninu awọn ẹranko.

Pẹlupẹlu, Pyrroloquinoline quinone ni ẹda antioxidant ati iṣẹ-ara Vitamin-bi, pẹlu awọn anfani pupọ lọpọlọpọ fun ọpọlọ ati ara. O ṣe igbelaruge ilera oye ati iranti nipa jijako alailoye mitochondrial ati aabo aabo awọn neurons lati ipalara bibajẹ. Awọn ẹkọ iṣọn-iwosan ninu awọn eniyan ti fihan pe quinone Pyrroloquinoline ṣe afikun iranti igba kukuru ati akiyesi, mu iṣelọpọ agbara ati ti ogbo ti ilera, ati dinku awọn asami ti iredodo, ati imudarasi awọn ikunsinu gbogbogbo ti alafia.

Bawo ni Pyrroloquinoline quinone(PQQ) iṣẹ́?

Awọn ẹkọ iwadii ṣe afihan ipa ti o yanilenu fun quinone Pyrroloquinoline ni safikun biogenesis mitochondrial. Iwọn hepatocytes ti o jẹ pẹlu PQQ ni 10-30 μM fun 24-48 h ti a ṣe afihan “alekun citrate synthase ati iṣẹ cytochrome c oxidase, idoti Mitotracker, akoonu DNA mitochondrial, ati atẹgun atẹgun sẹẹli. Indu ti ilana yii waye nipasẹ imuṣiṣẹ ti amuaradagba abuda amuṣiṣẹpọ amuaradagba (CREB) ati olugba gbigbasilẹ peroxisome-ṣiṣẹ coactivator-1α (PGC-1α), ọna ti a mọ lati ṣe ilana biogenesis mitochondrial. ” Ninu awọn ẹkọ vivo ni awọn eku tun ṣafihan awọn ipa anfani lati afikun ti ijẹẹmu pẹlu PQQ (2mg PQQ / kg ti ounje). Iwọnyi pẹlu awọn triglycerides pilasima ti dinku, inawo inawo ti o pọ si (ibamu pẹlu akoonu iredodo mitochondrial), ati ifarada ti ilọsiwaju si ischemia cardiac / reperfusion. Awọn awoṣe idanwo ti ọgbẹ-ọgbẹ ati ọgbẹ ọpa-ẹhin fihan pe Pyrroloquinoline quinone attenuates iku sẹẹli, eyiti o wa nipasẹ quinone Pyrroloquinoline n daabobo awọn olugba N-methyl-d-aspartic acid (NMDA). Awọn awoṣe ikawọn ti arun Parkinson fihan pe afikun Quinone Pyrroloquinoline dinku pipadanu iṣan neuronal, mu ki awọn ẹiyẹ atẹgun ifasẹhin ṣe agbara iwuwo, ati awọn fifunni nipasẹ awọn eto afikun.

Awọn anfani ti Quinone Pyrroloquinoline(PQQ) awọn anfani

Ninu ọpọlọ ati ara, PQQ ni awọn anfani pupọ.

- PQQ ṣe atilẹyin iṣẹ mitochondrial ti aipe

Mitochondria jẹ awọn iṣelọpọ agbara ninu awọn sẹẹli wa ati pe wọn ṣe ipa pataki ninu ilera wa gbogbogbo. PQQ nipa aabo mitochondria ti o wa lọwọ ati ṣe igbelaruge iran mitochondrial, nitorinaa gbejade ATP (Agbara). Diẹ mitochondria iṣẹ ṣiṣe, agbara diẹ sii.

- PQQ ṣe atilẹyin awọn ifosiwewe idagbasoke eegun

PQQ ṣe iwuri iṣelọpọ ti Faili Nkan Idagbasoke Nerve (NGF.), Ṣe aabo ati mimu pada ọpọlọ ti bajẹ ati awọn sẹẹli nafu, nitorinaa ṣe idilọwọ idinku isalẹ (ipadanu iranti, iṣoro ẹkọ, ati bẹbẹ lọ) nitori ọjọ-ori, ọpọlọ tabi awọn rudurudu neurodegenerative, ati igbelaruge aarun ati antioxidant awọn iṣẹ, ati aabo lati aisan okan ati awọn iṣẹlẹ isokosisi iṣan.

- PQQ ṣe idiwọ wahala eefin

PQQ n pese aabo idaabobo ẹda to lagbara, ṣe aabo awọn sẹẹli ninu ara lati ibajẹ oxidative ati iparun awọn ipilẹ. O ṣe atilẹyin iṣelọpọ agbara ti agbara ati ti ogbo ti ilera, ati pe a mọ cofactor aramada pẹlu ẹda ara ati iṣẹ ṣiṣe Vitamin-bii.

Yato si, PQQ le tun ni idiwọ ati tọju ibajẹ ẹdọ ati iṣẹ anticancer ti o lagbara.

Ohun elo / lilo ti Quinone Pyrroloquinoline(PQQ)

Ninu iwadi 2009 ti a gbejade ninu iwe irohin iṣoogun Ounjẹ, Pyrroloquinoline Quinone ti han lati ni agbara lati ṣe iranlọwọ lati daabobo. O wa ni lilo lati tọju itọju idinku (iranti pipadanu, iṣoro ẹkọ, ati bẹbẹ lọ) nitori ọjọ-ori, ọpọlọ tabi awọn rudurudu neurodegenerative, ati aabo lati aisan okan ati awọn iṣẹlẹ isokalẹ arun. Awọn abajade irufẹ ni a royin ninu iwadi atẹle ti ọdun 2011 ninu eyiti Pyrroloquinoline Quinone tun funni ni taara bi afikun ti ijẹun, bii awọn ohun mimu ti o jẹ orisun ọmu.

Bi o ṣe le to Quinone Pyrroloquinoline(PQQ)?

Ni igbesi aye, o le gba diẹ ninu PQQ lati diẹ ninu awọn ounjẹ jijẹ, o wa nipa ti ara rẹ ni ọpọlọpọ awọn ounjẹ ati ohun mimu, pẹlu awọn ata alawọ ewe, alubosa, tii tabi kiwifruit ati be be. Sibẹsibẹ, ti o ba ka iye ounjẹ ti eniyan ba jẹ ni gbogbo ọjọ, pupọ julọ ti wa ko le gba PQQ ti o to lati onje ojoojumọ wa. Nitorinaa, ti o ba fẹ awọn anfani diẹ sii ti o pọ si, o le gba PQQ diẹ sii nipasẹ diẹ ninu awọn ọna miiran, gẹgẹ bi afikun ijẹẹmu PQQ.

Reference:

  • Sisan, Kelsey (12 Kínní 2017). "Aro-ẹda Adayeba Le Dena Arun Ẹdọ”. msn.com. Fifẹyinti 14 Kínní 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). “Pungroloquinoline quinone: excretion nipasẹ methylotrophs ati iwuri fun idagba fun awọn microorganism”. Awọn alamọ-ẹrọ bioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). “Iparun biokemika: ipa ti PQQ bi agunmọ-ara ti ara ọmu? Iseda. 433 (7025): E10, ijiroro E11-2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). “Ẹgbẹ aporo ti kẹmika ti mọra kẹmika ti Hyphomicrobium X: ẹri ijẹri oniduro elekitironi fun ilana quinone kan”. Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-ti o gbẹkẹle dehydrogenases ti awọn kokoro arun acetic acid.ppl Microbiol Biotechnol. 2018 Oṣu kọkanla; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Oṣu Kẹsan 15. PMID: 30218379.

IKILO ATI IDAGBASOKE:

Ohun elo yii ni a Ta Fun Lilo Iwadi nikan. Awọn ofin Tita Waye. Kii ṣe fun Lilo Ọmọ eniyan, tabi Iṣoogun, Ile-iwosan, tabi Awọn lilo Ile.