Nicotinamide adenine dinucleotide (53-84-9)

March 15, 2020
SKU: 53-84-9
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Nicotinamide adenine dinucleotide (NAD) jẹ cofactor kan ti o ṣe iranlọwọ iṣelọpọ ti a rii ni gbogbo awọn sẹẹli ngbe. O wa ni awọn ọna meji …….


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

Nicotinamide adenine dinucleotide (53-84-9) fidio

Nicotinamide adenine dinucleotide (53-84-9) Sawọn ilana

ọja orukọ Nicotinamide adenine dinucleotide (NAD +)
Orukọ Kemikali Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
molikula agbekalẹ C21H27N7O14P2
molikula iwuwo 663.4 g / mol
Ibi Monoisotopic 663.109123 g / mol
Ofin Melting 160 ° C (320 ° F; 433 K)
Awọ White
Storage iwa afẹfẹ 2-8 ° C
solubility H2O: 50 mg / milimita
ohun elo Ounje ilera, ikunra, ifunni ifunni

ohun ti o jẹ Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) jẹ cofactor kan ti o ṣe iranlọwọ iṣelọpọ ti a rii ni gbogbo awọn sẹẹli ngbe. O wa ni awọn ọna meji, oxidized (NAD +) ati dinku (NADH).

Coenzyme NAD +, fọọmu oxidized ti NAD, ni akọkọ ṣe awari ni ọdun 1906 nipasẹ awọn onimọ-biochemist ti ilu Britain Arthur Harden ati William John Young. NAD + jẹ iṣelọpọ nipasẹ awọn ipa ọna gbigbepọ meji, eyiti o le ṣe lati ọna opopona de novo amino acid, tabi le ṣe iṣelọpọ nipasẹ atunlo awọn ohun elo ti iṣaju iṣaaju (bii nicotinamide) pada si ọna igbala ti NAD +. O jẹ ẹya iparun pyridine pataki ati ṣiṣẹ bi cofactor pataki ati aropo fun ọpọlọpọ awọn ilana ilana sẹẹli bọtini ti o ni irawọ-ara oxidative ati iṣelọpọ ATP, atunṣe DNA, ilana ilana eegun ti ikosile pupọ, ami ifihan kalsia iṣan ati iṣẹ Immunological.

NAD + jẹ ohun elo itẹwọgba gbigba elekitironi ni ifoyina nipa ẹda. O gba awọn elekitiro lati awọn ohun alumọni miiran ati dinku. O tun ṣe bi coenzyme ti itankale hydride ati aropo ti o jẹ NAD (+) polymerase, ati ṣe apẹrẹ coenzyme redox pẹlu dinku β-nicotinamide adenine dinucleotide (NADH). NAD (R) jẹ ribosylation ADP-ribose ninu ADP-A. O tun jẹ ipilẹṣẹ si cyclic ADP-ribose (ADP-ribosyl cyclase).

Gẹgẹbi ohun elo oxidant ninu iṣelọpọ sẹẹli, NAD (R) tun ṣe ipa kan ninu adenosine diphosphate (ADP) -ribose awọn aati gbigbe pẹlu polymerase diadenylate (ADP-ribose) ati ọpọlọpọ awọn ilana enzymatic miiran. O le ṣe idiwọ fun NAD lati ṣe idiwọ tabi dinku awọn atọgbẹ, akàn ati awọn arun ti o jọmọ ọjọ-ori miiran. Pẹlupẹlu, Awọn onigbọwọ NAD + le ṣiṣẹ synergistically pẹlu awọn afikun bii resveratrol lati ṣe iranlọwọ lati tunji mitochondria ati ja awọn arun ti ogbo.

Nicotinamide adenine dinucleotide(NAD +) awọn anfani

Gẹgẹbi oxidant ti o munadoko, Nicotinamide adenine dinucleotide fihan pe diẹ ninu awọn anfani to dara ninu awọn iṣẹ eniyan.

Mu iṣẹ ṣiṣe cellular rẹ ṣiṣẹ,

Mu agbara rẹ pọ si ni ti ara;

Imudarasi iṣẹ ọpọlọ, idojukọ ati iranti;

♦ Igbega ti iṣelọpọ rẹ;

Imudarasi oorun;

♦ Ṣe ilọsiwaju ṣiṣe sirtuin agbaye;

Ve Imudarasi ipa ọna antioxidant;

♦ dinku iredodo;

Balance Iwọntunwọnsi ti ilọsiwaju, iṣesi, iran ati gbigbọ;

Nicotinamide adenine dinucleotid tun jẹ afẹri taara ti isoniazid oogun naa, eyiti a lo ninu itọju tituberhma, ikolu ti o ṣẹlẹ nipasẹ ẹdọforo Mycobacterium. Ninu adanwo kan, eku ti a fun NAD fun ọsẹ kan ti ni ilọsiwaju ibaraẹnisọrọ-mitochrondrial iparun.

Ni afikun, Nicotinamide adenine dinucleotide (NAD +) tun ni idena ati itọju ti bulọki ọkan, iṣẹ ẹṣẹ oju-iwe ati ọpọlọ ariyanjiyan, egboogi-nicotinamide le ṣe alekun oṣuwọn ọkan pupọ ati titọ atriove ntricular ti o fa nipasẹ verapamil.

Nicotinamide adenine dinucleotide(NAD +) ohun elo:

  1. Ṣiṣe ayẹwo awọn atunlo awọn ohun elo aise, awọn adanwo iwadi imọ-jinlẹ.
  2. Ounje ilera, ikunra, ifunni ifunni
  3. API iṣelọpọ

Die Nicotinamide adenine dinucleotide(NAD +) iwadii

Awọn ensaemusi ti o ṣe ati lilo NAD + ati NADH jẹ pataki ninu oogun elegbogi mejeeji ati iwadii si awọn itọju iwaju fun arun. Coenzyme NAD + kii ṣe funrararẹ lo lọwọlọwọ bi itọju fun eyikeyi arun. Sibẹsibẹ, o n ṣe ikẹkọ fun lilo agbara rẹ ni itọju ailera ti awọn arun neurodegenerative bii arunAlzheimer's andParkinson.

Reference:

  • Belenky P, Bogan KL, Brenner C (2007). “NAD + iṣelọpọ agbara ni ilera ati aisan” (PDF). Awọn aṣa Biokem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Ṣe ifipamọ lati ipilẹṣẹ (PDF) ni ọjọ 4 Oṣu Keje ọdun 2009. Ti ṣe igbasilẹ 23 Oṣu keji ọdun 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). “Idanimọ ti mitochondrial NAD + olutaja ni Saccharomyces cerevisiae”. J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Oṣu Kẹrin ọdun 2003). “Nicotinamide adenine dinucleotide, olutọsọna ijẹ-ara ti gbigbemi, gigun ati arun”. Curr. Opin. Ẹjẹ Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). “Ipo redox ti nicotinamide-adenine dinucleotide ọfẹ ninu cytoplasm ati mitochondria ti ẹdọ eku”. Ṣekeko. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Oṣu Kẹwa ọdun 1980). “Nicotinamide adenine dinucleotide biosynthesis ati iṣẹ-ṣiṣe sẹẹli nucleotide pyridine ninu awọn eto makirobia”. Microbiol. Ifihan 44 (1): 83– PMC 373235. PMID 6997723.
  • Faranse SW. Pipọnti oti onibaje ṣe ipalara ẹdọ ati awọn ara miiran nipa idinku awọn ipele NAD⁺ ti o nilo fun iṣẹ ṣiṣe deacetylase sirtuin. Exp Mol Pathol. Ọdun 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Oṣu Kẹwa 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins ati NAD + ni Idagbasoke ati Itọju ti Ikun-ọkan ati Awọn Arun inu ọkan ati ẹjẹ. Resc 2018 Oṣu Kẹsan 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

IKILO ATI IDAGBASOKE:

Ohun elo yii ni a Ta Fun Lilo Iwadi nikan. Awọn ofin Tita Waye. Kii ṣe fun Lilo Ọmọ eniyan, tabi Iṣoogun, Ile-iwosan, tabi Awọn lilo Ile.