Raw Caffeic acid phenethyl ester lulú (104594-70-9)

December 28, 2018
SKU: 104594-70-9
5.00 jade ti 5 da lori 1 onibara rating

Raw Caffeic acid phenethyl ester lulú jẹ phenethyl oti ester ti caffeic acid ati kan bioactive ...... ..


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu
agbara: 1180kg / osù

Raw Caffeic acid phenethyl ester powder (104594-70-9) fidio

Raw Caffeic acid phenethyl ester lulú (104594-70-9) Sawọn ilana

ọja orukọ Raw Caffeic acid phenethyl ester lulú
Orukọ Kemikali Raw Caffeic acid phenethyl ester lulú;

Paffeate Phenylthyl; Pọtineti caffeate; Caffeic acid 2-phenylethyl ester; β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

brand NAti Ko si data fun wa
Oko Drug Tyrosine Kinase Awọn oludena, Awọn alakọja
CAS Number 104594-70-9
InChIKey SWUARLUWKZWEBQ-VQHVLOKHSA-N
molikula Fagbalagba C17H16O4
molikula Wmẹjọ 284.311 g / mol
Ibi Monoisotopic 284.31 g · mol-1
Isun Point 125-126ºC (dec.)
farabale ojuami 498.6 ± 45.0 ° C ni 760 mmHg
Idaji Ida-Omi Ko si Data Kan wa
Awọ ko ki nse funfun balau
Solubility Soluble ni acetate ethyl ni 50mg / milimita. Soluble ni DMSO ati ethanol.
Sdidiṣi Tti otutu Tọju ni 0 ° C
Raw Caffeic acid phenethyl ester lulú Application Agọ ti o ni ipa ẹjẹ si awọn ila laini akàn. Ẹlẹda ti ornithine decarboxylase ati amuaradagba tyrosine kinase. Ri lati wa ni oludasile kan pato ti ifosiwewe transcription iparun, NF-kB. O tun ti han lati ṣe pataki si ọna ọna lipoxygenase ti iṣelọpọ acid ti arachidonic nigba igbona.

Raw Caffeic acid phenethyl ester lulú (104594-70-9) Apejuwe

Raw Caffeic acid phenethyl ester lulú jẹ elethyl alcohol ester ti caffeic acid ati ẹya paati bioactive ti hive propolis, pẹlu antineoplastic, cytoprotective ati awọn iṣẹ imunomodulating. Lori isakoso, Raw Caffeic acid phenethyl ester powder (CAPE) jẹ ifagbarasi ti itumọ ọrọ-ọna itanna nu NF-kappa B ati o le dinku p70S6K ati awọn ọna titẹ agbara ti o wa ni Akt. Pẹlupẹlu, CAPE dena afikun igbega PDGF ti awọn sẹẹli ti iṣan sẹẹli ti o ni iṣan nipasẹ titẹsi p38 molugen-activated protein kinase (MAPK) ati factor factor-inducible (HIF) -1alpha ati mimu induction ti heme oxygenase-1 (HO-1) .

Caffeic acid phenethyl ester ni a ti royin lati ni egboogi-carcinogenic, egboogi-iredodo, ati awọn ohun-ini imunomodulatory. CAPE tun da idiwọ HIV-1 sinu. Awọn abuda aiṣedede-ẹtan ti a ti ro pe o jẹ nitori titẹkuro ọna ọna lipoxygenase ti iṣelọpọ acid ti arachidonic nipasẹ CAPE. Awọn ijinlẹ ti tun ṣe afihan CAPE lati jẹ alakoso kan pato ti o le lagbara lati ṣiiṣẹsi itọsi transcription nukilika NF kappa B, ti o jẹ eka ti amọradagba ti o nṣakoso transcription ti DNA. Caffeic Acid Phenethylester jẹ alakoso ti ODC ati Tyrosine Kinase

Caffeic acid phenethyl ester lulú (104594-70-9) Iṣaṣe ti Ise

Caffeic acid phenethyl ester jẹ ẹda ti propolis ti awọn oyinbo oyinbee, o ni idinaloju NF-κB ti idasilẹ nipasẹ ester phorbol, ceramide, okadaic acid, ati hydrogen peroxide nipa dena iyokuro ti p65 subunit ti NF-κB si nu. Ninu tito lẹsẹsẹ awọn ila laini, Caffeic acid phenethyl ester fihan ti o ni ileri antiproliferative pẹlu EC50 ti 1.76, 3.16, 13.7, ati 44.0 μM lodi si igun-ẹjẹ 26-L5, B16-BL6 melanoma, BHNA-1080 fibrosarcoma eniyan ati A549 agbọn eniyan. awọn eto ila-ara adenocarcinoma, lẹsẹsẹ. Caffeic acid phenethyl ester, bi apani agbara ti o lagbara, nfi agbara ipa apoptotiki ṣiṣẹ ni awọn ẹyin cellule granbellar nipasẹ didiye ilana Ibi-ipilẹ ROS ati idinamọ iṣẹ-ṣiṣe caspase. Pẹlupẹlu, Caffeic acid phenethyl ester attenuates pro-inflammatory phenotype of LPS-stimulated HSCs, ati sensitization induced ti HSCs si cytokines fibrogenic nipa didiye NF-κB signaling.

Ni vivo, Caffeic acid phenethyl ester (10 mg / kg, ip) yoo dẹkun idagba ati angiogenesis ti awọn èèmọ ipilẹ ni C57BL / 6 ati BALB / c eku ti a kọ pẹlu Lewis ẹdọfóró carcinoma, gẹẹmu carcinoma, ati awọn ẹyin miilanoma. Caffeic acid phenethyl ester (5, 10, 20 iwon miligiramu / kg) tun n ṣe afihan awọn ipa iṣan-ẹjẹ ni vivo nipasẹ dinku rẹmus iwuwo ati / tabi cellularity ti thymus ati Ọlọ.

Ohun elo Caffeic acid phenethyl ester lulú (104594-70-9)

▪ Ẹjẹ-ara

▪ Aantiinflammatory

▪ Idaniloju

▪ Blocker NFkB

anfani ti Caffeic acid phenethyl ester lulú (104594-70-9)

Pirofitii Phenethyl jẹ apo ti a ri ni propolis, adalu ti awọn oyin ṣe. Caffeic acid phenethyl ester (CAPE) le jẹ munadoko ninu idena ati itoju ti awọn ipalara ti o ni arun ti o ni imọran, eyiti o ni arun arthritis, lupus erythematosus ati psoriasis, orisirisi awọn aarun ati awọn arun ti o ni ikoko ti o tumọ, cataracts, ati awọn aisan miiran ti o ni ipalara ti iṣeduro oxidative. Pẹlupẹlu, a le lo CAPE lati ṣe itọju arun HIV kan nigba ti a ba dapọ ni igbọpọ oogun kan pẹlu nkan ti o ni idiwọ idapada HIV. O tun le ṣee lo si egboogi-atherosclerotic, antioxidative, cardioprotective, egboogi-isanraju ati antimitogenic.

IKILO ATI IDAGBASOKE:

Ohun elo yii ni a Ta Fun Lilo Iwadi nikan. Awọn ofin Tita Waye. Kii ṣe fun Lilo Ọmọ eniyan, tabi Iṣoogun, Ile-iwosan, tabi Awọn lilo Ile.