Quinone Pyrroloquinoline (PQQ) (72909-34-3)

March 11, 2019

Pyrroloquinoline quinone (PQQ), tun pe ni methoxatin, jẹ alabaṣiṣẹpọ redox. O wa ninu ile ati awọn ounjẹ bii kiwifruit, bi …… ..

 


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

 

Pyrroloquinoline quinone (PQQ) (72909-34-3) fidio

Awọn alaye Pyrroloquinoline quinone (PQQ) (72909-34-3) Awọn alaye ni pato

ọja orukọ Pungroloquinoline quinone (PQQ)
Orukọ Kemikali Coenzyme PQQ; Methoxatine; Quinone Pyrrolo-quinoline;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
molikula agbekalẹ C14H6N2O8
molikula iwuwo 330.21
Ibi Monoisotopic 330.012415 g / mol
Boliing Point 1018.6 ± 65.0 ° C (Asọtẹlẹ)
Itan filasi 569.8 ° C (1,057.6 ° F; 842.9 K)
iwuwo 1.963 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ Omi-pupa Alaga
Igbona ibi ipamọ 2-8 ° C
solubility Soluble ninu omi
ohun elo A ti royin PQQ lati ṣiṣẹ bi Vitamin ajile / cofactor omi ati bi antioxidant kan. O tun jẹ ipinnu fun lilo ninu awọn afikun ijẹẹmu, bii agbara, rirọpo ounjẹ, ati awọn ọpa odi ati be be lo.

 

ohun ti o jẹ Quinone Pyrroloquinoline(PQQ)?

Pyrroloquinoline quinone (PQQ), ti a tun pe ni methoxatin, jẹ cofactor redox. O wa ninu ile ati awọn ounjẹ bii kiwifruit, bi wara eniyan. Quinone Pyrroloquinoline jẹ pyrroloquinoline ti o ni awọn ẹgbẹ oxo ni awọn ipo 4- ati 5 ati awọn ẹgbẹ ọkọ oju opo ni awọn ipo 2-, 7- ati 9. O ni ipa kan bi Vitamin-tiotuka-omi ati cofactor. Ati, o jẹ olufihan ami kan fun awọn ibatan ti awọn ọlọjẹ ti o lowo ninu iyatọ ti awọn sẹẹli mammalian. Agbara atunlo giga ti PQQ le fun ni ipa elegbogi ni idaabobo lodi si neurodegeneration ati akàn. (Gẹgẹbi oluranlọwọ redox, Quinone Pyrroloquinoline jẹ idurosinsin pupọ ati pe o le kopa ninu awọn aati ọgọrun diẹ sii ju awọn antioxidants miiran lọ, bii ascorbic acid, quercetin, ati epicatechin.

Quinone ti Pyrroloquinoline jẹ biofactor aramada, ati pe a mọ ọ bi ọlẹ-inu enzymu ninu awọn kokoro arun. Awọn iwadii fihan pe quinone Pyrroloquinoline le ti wa ni igbagbogbo jakejado irọlẹ ti ibi ati itankalẹ. Gẹgẹbi ifosiwewe agbara ọgbin, o wa ninu idagba ti awọn ẹranko ati eniyan. Pungroloquinoline quinone ni a ṣe ijabọ lati kopa ninu ọpọlọpọ awọn iṣẹ ti ibi pẹlu awọn anfani iwalaaye ti o han gbangba (fun apẹẹrẹ, idagbasoke ọmọ tuntun ati iṣẹ ibisi) ninu awọn ẹranko.

Pẹlupẹlu, Pyrroloquinoline quinone ni ẹda antioxidant ati iṣẹ-ara Vitamin-bi, pẹlu awọn anfani pupọ lọpọlọpọ fun ọpọlọ ati ara. O ṣe igbelaruge ilera oye ati iranti nipa jijako alailoye mitochondrial ati aabo aabo awọn neurons lati ipalara bibajẹ. Awọn ẹkọ iṣọn-iwosan ninu awọn eniyan ti fihan pe quinone Pyrroloquinoline ṣe afikun iranti igba kukuru ati akiyesi, mu iṣelọpọ agbara ati ti ogbo ti ilera, ati dinku awọn asami ti iredodo, ati imudarasi awọn ikunsinu gbogbogbo ti alafia.

 

Bawo ni Pyrroloquinoline quinone(PQQ) iṣẹ́?

Awọn ijinlẹ eku fihan ipa iyalẹnu fun Pyrroloquinoline quinone ni safikun biogenesis mitochondrial. Awọn hepatocytes eku ti a dapọ pẹlu PQQ ni 10-30 μM fun 24-48 h ṣe afihan “iṣelọpọ citrate pọ si ati iṣẹ cytochrome c oxidase, abawọn Mitotracker, akoonu DNA mitochondrial, ati atẹgun atẹgun cellular. Atilẹjade ilana yii waye nipasẹ ṣiṣiṣẹ ti amuaradagba idapọ idaamu idaamu CAMP (CREB) ati olugba ti n mu olugbaja peroxisome ṣiṣẹ-ac coactivator-1α (PGC-1α), ọna ti a mọ lati ṣakoso ilana biogenesis mitochondrial. ” Ninu awọn ẹkọ inu vivo ninu awọn eku tun fihan awọn ipa anfani lati ifikun ounjẹ pẹlu PQQ (2mg PQQ / kg ti ounjẹ). Iwọnyi pẹlu pilasima triglycerides dinku, lilo inawo ti o pọ sii (ti o ni ibatan pẹlu akoonu mitochondrial ẹdọ), ati ifarada ti o dara si ischemia inu ọkan / ifunjade. Awọn awoṣe iwadii ti ikọlu ati ọgbẹ ẹhin fihan pe Pyrroloquinoline quinone attenuates iku sẹẹli neuronal, ni apakan nipasẹ Pyrroloquinoline quinone idaabobo awọn olugba N-methyl-d-aspartic acid (NMDA). Awọn awoṣe eku ti arun Arun Parkinson fihan pe Pyrroloquinoline quinone supplementation dinku pipadanu neuronal, mu ki agbara ifunni awọn eefun atẹgun ti ifaseyin ṣe, ati ipese aabo ni awọn ọna ṣiṣe ni afikun.

 

Awọn anfani ti Quinone Pyrroloquinoline(PQQ) awọn anfani

Ninu ọpọlọ ati ara, PQQ ni awọn anfani pupọ.

- PQQ ṣe atilẹyin iṣẹ mitochondrial ti aipe

Mitochondria jẹ awọn iṣelọpọ agbara ninu awọn sẹẹli wa ati pe wọn ṣe ipa pataki ninu ilera wa gbogbogbo. PQQ nipa aabo mitochondria ti o wa lọwọ ati ṣe igbelaruge iran mitochondrial, nitorinaa gbejade ATP (Agbara). Diẹ mitochondria iṣẹ ṣiṣe, agbara diẹ sii.

- PQQ ṣe atilẹyin awọn ifosiwewe idagba iṣan

PQQ ṣe iwuri iṣelọpọ ti Faili Nkan Idagbasoke Nerve (NGF.), Ṣe aabo ati mimu pada ọpọlọ ti bajẹ ati awọn sẹẹli nafu, nitorinaa ṣe idilọwọ idinku isalẹ (ipadanu iranti, iṣoro ẹkọ, ati bẹbẹ lọ) nitori ọjọ-ori, ọpọlọ tabi awọn rudurudu neurodegenerative, ati igbelaruge aarun ati antioxidant awọn iṣẹ, ati aabo lati aisan okan ati awọn iṣẹlẹ isokosisi iṣan.

- PQQ ṣe idiwọ wahala ipanilara

PQQ n pese aabo idaabobo ẹda to lagbara, ṣe aabo awọn sẹẹli ninu ara lati ibajẹ oxidative ati iparun awọn ipilẹ. O ṣe atilẹyin iṣelọpọ agbara ti agbara ati ti ogbo ti ilera, ati pe a mọ cofactor aramada pẹlu ẹda ara ati iṣẹ ṣiṣe Vitamin-bii.

Yato si, PQQ le tun ni idiwọ ati tọju ibajẹ ẹdọ ati iṣẹ anticancer ti o lagbara.

Ohun elo / lilo ti Quinone Pyrroloquinoline(PQQ)

Ninu iwadi 2009 ti a gbejade ninu iwe irohin iṣoogun Ounjẹ, Pyrroloquinoline Quinone ti han lati ni agbara lati ṣe iranlọwọ lati daabobo. O wa ni lilo lati tọju itọju idinku (iranti pipadanu, iṣoro ẹkọ, ati bẹbẹ lọ) nitori ọjọ-ori, ọpọlọ tabi awọn rudurudu neurodegenerative, ati aabo lati aisan okan ati awọn iṣẹlẹ isokalẹ arun. Awọn abajade irufẹ ni a royin ninu iwadi atẹle ti ọdun 2011 ninu eyiti Pyrroloquinoline Quinone tun funni ni taara bi afikun ti ijẹun, bii awọn ohun mimu ti o jẹ orisun ọmu.

 

Bi o ṣe le to Quinone Pyrroloquinoline(PQQ)?

Ni igbesi aye, o le gba diẹ ninu PQQ lati inu itọju onjẹ diẹ, o jẹ ti ara ni ọpọlọpọ awọn ounjẹ ati awọn ohun mimu, pẹlu ata alawọ, parsley, tii tabi kiwifruit ati bẹbẹ lọ Sibẹsibẹ, ti o ba ka iye ounjẹ ti eniyan n jẹ ni gbogbo ọjọ, pupọ julọ ti wa ko le gba PQQ ti o to lati inu ounjẹ ojoojumọ wa. Nitorinaa, ti o ba fẹ awọn anfani ti o tobi julọ, o le gba PQQ diẹ sii nipasẹ awọn ọna miiran, gẹgẹ bi afikun ounjẹ ounjẹ PQQ.

 

Reference:

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