Nicotinamide riboside kiloraidi (NR-CL) (23111-00-4)

March 11, 2020

Nicotinamide riboside (NR) jẹ awari tuntun ti nicotinamide adenine dinucleotide (NAD +) vitamin ṣaaju. Awọn …….

 


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

 

Nicotinamide riboside kiloraidi (NR-CL) (23111-00-4) fidio

Nicotinamide riboside kiloraidi (NR-CL) (23111-00-4) Sawọn ilana

ọja orukọ Nicotinamide riboside kiloraidi (NR-CL) (23111-00-4)
Orukọ Kemikali NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium kiloraidi; Nicotinamide ribose kiloraidi; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium kiloraidi; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium kiloraidi; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
CAS Number 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
molikula agbekalẹ C11H15ClN2O5
molikula iwuwo 290.7002
Ibi Monoisotopic 290.066949 g / mol
Ofin Melting N / A
Awọ funfun
Storage iwa afẹfẹ -20 ° C Dasita
ohun elo awọn afikun ijẹẹmu, aaye elegbogi

 

ohun ti o jẹ Nicotinamide riboside kiloraidi(NR-CL)?

Nicotinamide riboside (NR) jẹ iṣapẹẹrẹ nicotinamide tuntun adenine dinucleotide (NAD +) Vitamin iṣaju iṣaju. Fọọmu kirisita ti NR kiloraidi ni a pe ni NIAGEN, eyiti o jẹ fọọmu sintetiki ti nicotinamide riboside ati orisun lati eyiti nicotinamide ni irisi eroja nicotinic le jẹ bioavare ati pe gbogbo eniyan ni a ka si ailewu (GRAS). NR kiloraidi jẹ koko-ọrọ ti awọn akiyesi awọn eroja eroja titun ti ijẹẹmu meji, eyiti a lo ni awọn afikun awọn ounjẹ.

Nicotinamide Riboside Chloride jẹ eroja ti ara ti o wa ninu wara. O jẹ ibatan gangan si niacin ati awọn ọna miiran ti Vitamin B3. Diẹ ninu awọn iwadii ti ri pe Nicotinamide Riboside Chloride ni diẹ ninu awọn abuda alailẹgbẹ ti o le ṣe alekun iṣelọpọ ọkan lati ṣe iranlọwọ sisun awọn kalori diẹ sii ati lati ṣe idiwọn iwuwo. Ni afikun si pipadanu iwuwo, o tun ṣe iranlọwọ igbelaruge iṣẹ iṣan, mu inawo agbara pọ si, ati idinku awọn ifosiwewe eewu ti àtọgbẹ.

Pẹlupẹlu, iwadii kan ninu eniyan ti fihan pe awọn mejeeji Nicotinamide Riboside Chloride ṣe igbega awọn ipele NAD +, eyiti o ṣe iranlọwọ lati ṣe ameliorate diẹ ninu awọn ipo ti o jọmọ ọjọ-ori, botilẹjẹpe o ti pẹ lati mọ sibẹsibẹ bawo ni yoo ṣe jẹ.

 

anfani ti Nicotinamide riboside kiloraidi(NR-CL)

Nicotinamide riboside kiloraidi jẹ fọọmu ti iṣelọpọ ti nicotinamide riboside, awọn anfani / iṣẹ rẹ jẹ kanna bi nicotinamide riboside. O n kopa ninu iṣelọpọ ninu ara, o le ṣee lo lati ṣe idiwọ pellagra tabi arun aarun ifa niacin miiran ati lati dinku idaabobo awọ ati awọn triglycerides ninu ẹjẹ. O tun lo lati dinku eewu ikọlu ọkan ninu awọn eniyan pẹlu idaabobo awọ giga ti o ti ni ikọlu ọkan tẹlẹ. Nigbakan o lo lati tọju arun iṣọn-alọ ọkan ninu iṣọn-alọ ọkan (atherosclerosis), daabobo aabo ọpọlọ ati ẹdọ (arun inu ọkan ati ẹjẹ, àtọgbẹ, arun Alzheimer).

Yato si, Nicotinamide riboside kiloraidi tun ni awọn anfani miiran ni eniyan:

  • Walẹ deede ati gbigba ti awọn ọlọjẹ ati awọn ọra;
  • Iranlọwọ ṣe iyipada pataki tryptophan amino acid sinu niacin;
  • Din ìgbagbogbo, ati dinku awọn abajade ti mu awọn oogun apakokoro nitori ẹnu gbigbẹ ati iṣoro urin;
  • Ṣe igbelaruge iṣelọpọ eefin nucleic acid ati idiwọ ti ogbo awọn ara ati awọn ara, nitorinaa iyọrisi idi ti idaduro ti ogbo;
  • O lọra isan iṣan ti iṣan, ipọnju spastic ati ọwọ ati ẹsẹ neuritis;
  • Itoju hypometabolism ti apọju ati imudara ti iṣelọpọ;
  • Idena ati itọju ti aipe Vitamin B6;
  • Itoju ti aisan eefin carpal;
  • Ṣe iranlọwọ pipadanu iwuwo ati arawa iṣẹ iṣan.
  • Mu ilọsiwaju ara wa dara si awọn sẹẹli alakan
  • Dena pipadanu igbọran
  • Ṣe diuretic adayeba kan.
  • Mu awọn abere ti o tobi le ṣe ifunni afẹsodi oogun ati ni ipa detoxification to dara.
  • Imudara iṣẹ ti awọn sẹẹli kẹtimiẹli, ati awọn iṣẹ ti awọn sẹẹli miiran ninu ara eniyan, lati jẹ ki awọ ara tàn.

 

Nicotinamide riboside kiloraidi(NR-CL) lilo

Nitori Nicotinamide riboside kiloraidi ni awọn ohun-ini oogun ti o ni anfani, o ma nlo nigbagbogbo ni awọn afikun ounjẹ, oogun ati aaye ifunni.

 

 

Reference:

  • Conze D, Brenner C, Kruger CL. Ailewu ati Ti iṣelọpọ ti Iṣakoso akoko-gigun ti NIAGEN (Nicotinamide Riboside Chloride) ni Randomized, Afọju Meji, Ibi idanwo Iṣakoso-iwosan ti placebo ti Awọn Agbalagba Abo ilera. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
  • Bogan, KL, Brenner, C. (2008). "Nicotinic acid, nicotinamide, ati nicotinamide riboside: igbelewọn molikula ti awọn vitamin NAD + ṣaaju ṣaaju ninu ounjẹ eniyan". Annu. Rev. Nutr. 28: 115-130. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
  • Chi Y, Sauve AA (Oṣu kọkanla 2013). "Nicotinamide riboside, itọpa ti o wa ninu awọn ounjẹ, jẹ Vitamin B3 pẹlu awọn ipa lori iṣelọpọ agbara ati neuroprotection". Ile-iwosan Curr Opin Nutr Metab Itọju. 16 (6): 657-61. ṣe: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.