N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020

NACET (N-Acetylcysteine ​​ethyl ester) jẹ aratuntun lipophilic cell-permeable itọsẹ cysteine ​​pẹlu ẹya ẹya-ara ti oogun-oogun ati iyalẹnu… ..

 


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) fidio

NACET (59587-09-6) Awọn alaye ni pato

ọja orukọ NACET (59587-09-6)
Orukọ Kemikali R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, eyl etster;
N-ACETYL-L-CYSTEINE ETHYL;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, eyl etster;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
molikula agbekalẹ C7H13NO3S
molikula iwuwo 191.25
Ibi Monoisotopic 191.061614 g / mol
Ofin Melting 44.1-44.5 ° C
Boiling Point  337.6 ± 32.0 ° C (Asọtẹlẹ)
iwuwo 1.138 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ Ko ki nse funfun balau
ohun elo Nootropics ati awọn oogun ọlọgbọn, le ṣee lo fun igbelaruge iranti, idojukọ, àtinúdá, oye ati iwuri. O tun le ṣee lo bi afikun ti ijẹun.

 

ohun ti o jẹ NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) jẹ itọsẹ ti ara ẹni lipophilic cell-permeable cysteine ​​pẹlu ẹya-ara ti oogun-oogun oniye ati agbara apanirun ti iyalẹnu. NACET ni bioavailability ti ẹnu giga. O jẹ apaniyan ti o lagbara ati aṣaaju ọlọrọ ti GSH, eyiti o ni ibatan si acid ọfẹ N-acetyl -L yatọ si -cysteine ​​(NAC). NACET jẹ lulú funfun ni iwọn otutu yara ati tio tuka larọwọto ninu omi ati awọn nkan alumọni.

NAC jẹ itọsẹ ti cysteine. Lati awọn ọdun 1970, o ti lo lati ṣe itọju awọn alaisan pẹlu iṣọn-ẹjẹ acetaminophen ati awọn aarun ara, ati pe o jẹ ọja bi oogun ati awọn afikun ijẹẹmu. Ni afiwe pẹlu NAC, NACET ni irọra ti o ga julọ ati awọn ohun-ini elegbogi ti a ti ni ilọsiwaju gaan. O ni agbara lati rọpo NAC elegbogi, bi oluranlowo mucolytic, ẹda ara, olutaja ti GSH, apakokoro paracetamol, ati pe o kere ju Donor ti onisẹ gaseous H 2 S ati oluranlowo aabo UV.

Ni afikun, nucleophilicity lagbara ati idinku agbara ti NACET tun ti jẹri ninu awọn sẹẹli ẹjẹ pupa eniyan. O ti rii lati ṣajọpọ ninu awọn sẹẹli ẹjẹ pupa eniyan, ni didakoju didena ibajẹ eefun ti a fa nipasẹ hydroperoxides. Nitorinaa, agbara NACET gegebi antioxidant ti o fa idena-nitrite pọ julọ ju ti ti NAC methemoglobinemia ati awọn ifogun agbara miiran. Awọn ẹkọ-ẹkọ ninu awọn eku ti ri pe NACET ti wa ni yiyara pupọ ju NAC lọ nigbati NACET nṣakoso ẹnu. O ni anfani lati wọ awọn sẹẹli ati lati ṣe NAC ati cysteine, eyiti o mu ki imi-ọjọ hydrogen sulfide (H (2) S) pọ si ninu iṣan kaakiri. O jẹ oludiran to dara fun lilo ẹnu gẹgẹbi olupilẹṣẹ H (2) S,

 

Awọn anfani ti NACET (N-Acetylcysteine ​​ethyl ester)

Gẹgẹbi antioxidant ti o lagbara, NACET ni awọn anfani nla lori ilera eniyan.

- Mu awọn ipo ilera lọpọlọpọ ati yọ awọn aami aisan ti aisan ọpọlọ;

- Itọju ti overdoses acetaminophen, aabo ti awọn kidinrin ati ẹdọ;

- Ṣe ilọsiwaju iṣẹ ẹdọfóró nipasẹ idinku iredodo ati fifọ imu, nitorina o dinku awọn arun atẹgun onibaje.

- Ṣe igbega si ilera ọpọlọ nipa ṣiṣakoso glutamate ati afikun glutathione, ni a le lo lati ṣe itọju awọn aisan bii arun Alzheimer ati arun Parkinson;

- Mu ilora dara si awọn ọkunrin ati obinrin

- Le mu iṣẹ ajẹsara dara si ni ọpọlọpọ awọn aarun, dena ibajẹ eefun si ọkan, ati dinku eewu arun ọkan.

- Ṣe Duro Suga Ẹjẹ Nipa Idinku Iredodo ni Awọn sẹẹli Ọra

 

Ibere ​​lori ẹrọ NAIF (N-Acetylcysteine ​​ethyl ester)

Nitori NACET ti ṣe afihan awọn ipa nla lori aisan ọgbọn ori, arun atẹgun onibaje ati aisan ori, igbagbogbo ni a lo bi oogun ati afikun ijẹẹmu lati daabobo ọpọlọ, mu ilọsiwaju iṣaro ati ti ara ṣe, lati mu iranti, imọ ati iṣẹ elere ga si.

 

Reference:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): itọsi ara-ara ti o jẹ ohun-ara cysteine ​​cysteine ​​aramada pẹlu ẹya elegbogi elegbogi dani ati ailagbara ipakokoro oogun. Pharmacol Biokemisi. 2012 Oṣu keji 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Oṣu Kẹsan 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ati N-acetyl-L-cysteine ​​ethyl ester (NACET)-Awọn oludije oogun orisun -Cysteine ​​pẹlu awọn profaili eleto ti iṣoogun fun lilo ẹnu bi KO, H2S ati awọn olupese GSH ati bi awọn antioxidants: Awọn abajade ati Akopọ. 2018 Oṣu keji; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Atunwo. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester bi olutọju GSH ni awọn sẹẹli akọkọ endothelial ẹyin: Iwadi kan afiwera pẹlu awọn oogun miiran. 2018 Oṣu Kẹwa; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Oṣu Kẹwa 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ati N-acetyl-L-cysteine ​​ethyl ester (NACET) –Awọn oludije oloogun orisun -Cysteine ​​pẹlu awọn profaili eleto ti iṣoogun fun lilo ẹnu bi KO, H2S ati awọn olupese GSH ati bi awọn antioxidants: Awọn abajade ati Akopọ. Iwe akosile ti Onínọmbà elegbogi. Iwọn didun 8, Efa 1, Kínní 2018, Oju-iwe 1-9.