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N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

NACET (N-Acetylcysteine ​​ethyl ester) jẹ aratuntun lipophilic cell-permeable cysteine ​​cysteine ​​pẹlu ẹya ẹya elegbogi elektokokinetic dani ati o lapẹẹrẹ… ..


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

Apejuwe

NACET (59587-09-6) Awọn alaye ni pato

ọja orukọ NACET (59587-09-6)
Orukọ Kemikali R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, eyl etster;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, eyl etster;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
molikula agbekalẹ C7H13NO3S
molikula iwuwo 191.25
Ibi Monoisotopic 191.061614 g / mol
Ofin Melting 44.1-44.5 ° C
Boiling Point 337.6 ± 32.0 ° C (Asọtẹlẹ)
iwuwo 1.138 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ Ko ki nse funfun balau
ohun elo Nootropics ati awọn oogun ọlọgbọn, le ṣee lo fun igbelaruge iranti, idojukọ, àtinúdá, oye ati iwuri. O tun le ṣee lo bi afikun ti ijẹun.

ohun ti o jẹ NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) jẹ itọsi arara lipophilic cell-permeable cysteine ​​cysteine ​​pẹlu ẹya ẹya elegbogi elegbogi dani ati agbara ipanilara ti o lapẹẹrẹ. NACET ni bioav wiwa ikunra giga. O jẹ antioxidant ti o lagbara ati iṣaju ọrọ ọlọrọ ti GSH, eyiti o ni ibatan si acid-ọfẹ rẹ ti N-acetyl -L yatọ si -cysteine ​​(NAC). NACET jẹ lulú funfun ni iwọn otutu yara ati pe o ni itusilẹ ninu omi ati awọn nkan gbigbẹ Organic.

NAC jẹ itọsẹ ti cysteine. Lati awọn ọdun 1970, o ti lo lati ṣe itọju awọn alaisan pẹlu iṣọn-ẹjẹ acetaminophen ati awọn aarun ara, ati pe o jẹ ọja bi oogun ati awọn afikun ijẹẹmu. Ni afiwe pẹlu NAC, NACET ni irọra ti o ga julọ ati awọn ohun-ini elegbogi ti a ti ni ilọsiwaju gaan. O ni agbara lati rọpo NAC elegbogi, bi oluranlowo mucolytic, ẹda ara, olutaja ti GSH, apakokoro paracetamol, ati pe o kere ju Donor ti onisẹ gaseous H 2 S ati oluranlowo aabo UV.

Ni afikun, ipilẹ nucleophilicity ti o lagbara ati idinku agbara NACET tun ti han ni awọn sẹẹli pupa ẹjẹ eniyan. O ti ri lati kojọpọ ninu awọn sẹẹli pupa ẹjẹ eniyan, ni ilodi si ija ni ibajẹ bibajẹ nipasẹ hydroperoxides. Nitorinaa, agbara ti NACET bi antioxidant anti-nitrite jẹ tobi pupọ ju ti ajẹsara ti NAC methemoglobinemia ati awọn ohun elo agbara lagbara miiran. Ijinlẹ ninu awọn eku ti rii pe NACET n gba iyara pupọ ju NAC nigbati a ṣakoso abojuto NACET. O ni anfani lati tẹ awọn sẹẹli ati gbejade NAC ati cysteine, eyiti o mu ki hydrogen sulfide (H (2) S) pọ ni san kaakiri. O jẹ oludije ti o dara fun lilo ikunra gẹgẹbi olupilẹṣẹ H (2) S,

Awọn anfani ti NACET (N-Acetylcysteine ​​ethyl ester)

Gẹgẹbi antioxidant ti o lagbara, NACET ni awọn anfani nla lori ilera eniyan.

- Ṣe ilọsiwaju awọn ipo ilera pupọ ati yọ awọn aami aisan ti aisan ọpọlọ;

- Itoju ti overdoses acetaminophen, aabo ti awọn kidinrin ati ẹdọ;

- Ṣe ilọsiwaju iṣẹ ẹdọfóró nipa idinku iredodo ati fifọ mucus, nitorinaa din idinku awọn aarun atẹgun onibaje.

- Ṣe igbelaruge ilera ọpọlọ nipa ṣiṣe ilana ijẹ-ara ati afikun iyọjẹ, le ṣee lo lati tọju awọn arun bii arun Alzheimer ati arun Parkinson;

- Imudarasi irọyin ninu awọn ọkunrin ati awọn obinrin

- Ṣe ilọsiwaju iṣẹ ajesara ni ọpọlọpọ awọn arun, ṣe ibajẹ eero ti okan, ati dinku eewu arun aisan.

- Ṣe Iduroṣinṣin Ikun ẹjẹ Nipa Iyokuro Ibajẹ ninu Awọn ẹyin Ọra

Ibere ​​lori ẹrọ NAIF (N-Acetylcysteine ​​ethyl ester)

Nitori NACET ti ṣe afihan awọn ipa nla lori aisan ọpọlọ, arun atẹgun onibaje ati aisan ọpọlọ, a nlo igbagbogbo bi oogun ati afikun ijẹẹmu lati daabobo ọpọlọ, mu ilọsiwaju ti ọpọlọ ati iṣe ti ara, bii lati jẹki iranti, oye ati iṣẹ ere ije.

Reference:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): itọsi ara-ara ti o jẹ ohun-ara cysteine ​​cysteine ​​aramada pẹlu ẹya elegbogi elegbogi dani ati ailagbara ipakokoro oogun. Pharmacol Biokemisi. 2012 Oṣu keji 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Oṣu Kẹsan 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ati N-acetyl-L-cysteine ​​ethyl ester (NACET)-Awọn oludije oogun orisun -Cysteine ​​pẹlu awọn profaili eleto ti iṣoogun fun lilo ẹnu bi KO, H2S ati awọn olupese GSH ati bi awọn antioxidants: Awọn abajade ati Akopọ. 2018 Oṣu keji; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Atunwo. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester bi olutọju GSH ni awọn sẹẹli akọkọ endothelial ẹyin: Iwadi kan afiwera pẹlu awọn oogun miiran. 2018 Oṣu Kẹwa; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Oṣu Kẹwa 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) ati N-acetyl-L-cysteine ​​ethyl ester (NACET) –Awọn oludije oloogun orisun -Cysteine ​​pẹlu awọn profaili eleto ti iṣoogun fun lilo ẹnu bi KO, H2S ati awọn olupese GSH ati bi awọn antioxidants: Awọn abajade ati Akopọ. Iwe akosile ti Onínọmbà elegbogi. Iwọn didun 8, Efa 1, Kínní 2018, Oju-iwe 1-9.

IKILO ATI IDAGBASOKE:

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