NADP iyọ disodium (24292-60-2)

March 15, 2020
SKU: 164656-23-9
5.00 jade ti 5 da lori 1 onibara rating

Nicotinamide adenine dinucleotide fosifeti (NADP +) jẹ cofactor ti a lo ninu awọn ifura anabolic. -Nicotinamide adenine ……


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

NADP iyọ disodium (24292-60-2) fidio


β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (NADP disodium salt)awọn ilana

ọja orukọ β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (iyọ disodium NADP)
Orukọ Kemikali NADP Disodium; Nadide fosifeti disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium iyọ;
CAS Number 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
molikula agbekalẹ C21H26N7Na2O17P3
molikula iwuwo 787.37
Ibi Monoisotopic 787.039342 g / mol
Ofin Melting 175-178 ° C
Awọ Yellow
Storage iwa afẹfẹ -20 ° C
omi solubility > 50 g / L
ohun elo Coenzyme ni awọn aerobic ati awọn ohun elo anaerobic

Kini β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (iyọ disodium NADP)?

Nicotinamide adenine dinucleotide fosifeti (NADP +) jẹ cofactor ti a lo ninu awọn ifura anabolic. -Nicotinamide adenine dinucleotide fosifeti iyọ disodium jẹ iyọ disodium ti NADP +, o jẹ coenzyme pataki fun ifun ọti-ọkan ti glukosi ati ito ara eniyan ti awọn nkan miiran. Ati pe o waye ni pipọ ninu iṣan ara, paapaa ni ẹdọ.

Nicotinamide adenine dinucleotide fosifeti (NADP) ati NADPH ṣe idapo redox. Iwọn NADPH / NADP ṣe ilana agbara iṣipopada iṣan, pataki idahun anaerobic, nitorina ni ipa lori idahun ti ase ijẹ-ara ninu ara. Awọn apẹẹrẹ jẹ eepo ati iṣelọpọ acid aye. NADP tun jẹ bata coenzyme ni ọpọlọpọ awọn eto cytochrome P450 ati awọn eto ifesi oxidase / reductase bii eto thioredoxin reductase / thioredoxin.

NADPH n pese idinku awọn deede fun awọn aati biosynthetic ati pese awọn ipa ipa-ọna lati yago fun majele ti awọn ẹya atẹgun ifamọra (ROS), nitorinaa tun ṣe atunṣe glutathione (GSH). O tun nlo ninu awọn ipa ọna anabolic bii idapọmọra idapọmọra ati ọra acids itẹsiwaju.

Ni afikun, eto NADPH tun jẹ iduro fun ṣiṣẹda awọn ipilẹṣẹ ọfẹ ni awọn sẹẹli ajesara nipasẹ NADPH oxidase. Wọn lo awọn ipilẹṣẹ ọfẹ yii lati pa awọn oniro-arun run ni ilana ti a pe ni fifa atẹgun. O jẹ idinku deede ti orisun aromatiki cytochrome P450 hydroxylated hydroxylated, awọn sitẹriọdu, ọti ati awọn oogun.

ohun elo ti dis-Nicotinamide adenine dinucleotide fosifeti iyọ disodium

Nicotinamide adenine dinucleotide fosifeti (NADP) ati NADPH ṣe idapo redox. NADP / NADPH jẹ coenzyme kan ti o ṣe atilẹyin awọn atunṣe redox nipasẹ gbigbe ti awọn elekitironi ni ọpọlọpọ awọn ohun elo, pataki awọn ifura anaerobic bii eepo ati iṣelọpọ acid. NADP / NADPH jẹ tọkọtaya coenzyme ni ọpọlọpọ awọn eto cytochrome P450 ati awọn eto ifisi ohun elo oxidase / reductase, bii eto thioredoxin reductase / thioredoxin.

Awọn ensaemusi miiran ti o lo NADP bi coenzyme kan ni: Ọra dehydrogenase: NADP ti o gbẹkẹle; ADAM Aromatic: igbẹkẹle NADP; Ferredoxin-NADP reductase; Dehydrogenase L-Fucose; Gabase; Itumọ gbigbe uridyl Galactose-1-fosifeti; Glukosi glukosi; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP kan pato; Isocitric dehydrogenase; Awọn enzymu Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase ati Succinic semialdehyde dehydrogenase.

Reference:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD iṣọn-alọ ọkan Nkan ina Idahun Imọlẹ NADP ni Awọn Eweko. Iwaju Ohun ọgbin Sci. 2019 Oṣu Keje 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Ẹwẹ toje ti iṣan jẹ NAD + ati NADP + glycohydrolase pẹlu iyasọtọ awọn ohun-ini enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Oṣu Kẹjọ 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. kaakiri, Itankalẹ, Ẹrọ imọ-ẹrọ Catalytic, ati Awọn iṣẹ-iṣe ti ẹkọ-ara ti Flavin-based Electron-Bifurcating NADH-Dependering Ferredoxin idinku: NADP + Oxidoreductase. Microbiol iwaju. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. “Eto ati iṣẹ ti NAD kinase ati phosphatase NADP: awọn ensaemusi bọtini ti o ṣe ilana iwọntunwọnsi iṣan ti NAD (H) ati NADP (H)”. Ẹkọ-ara, Ẹkọ nipa imọ-ẹrọ, ati Imọ-ọna biokemika. 72 (4): 919-30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. “Ifipamọ ti Awọn atọka Enzyme-Coenzyme ni FAD ati NADP Binding Adrenodoxin idinku-Enzymu Kan ti aitọ”. Iwe akosile ti Itankalẹ ti iṣan. 85 (5-6): 205-218. Bibcode: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

IKILO ATI IDAGBASOKE:

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