NADP ainipẹkun iyọ (24292-60-2) fidio
β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (NADP disodium salt)awọn ilana
| ọja orukọ | β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (iyọ disodium NADP) |
| Orukọ Kemikali | NADP Disodium; Nadide fosifeti disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium iyọ; |
| CAS Number | 24292-60-2 |
| InChIKey | UNRRSQIQTVFDLS-WUEGHLCSSA-L |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+] |
| molikula agbekalẹ | C21H26N7Na2O17P3 |
| molikula iwuwo | 787.37 |
| Ibi Monoisotopic | 787.039342 g / mol |
| Ofin Melting | 175-178 ° C |
| Awọ | Yellow |
| Storage iwa afẹfẹ | -20 ° C |
| omi solubility | > 50 g / L |
| ohun elo | Coenzyme ni awọn aerobic ati awọn ohun elo anaerobic |
Kini β-Nicotinamide adenine dinucleotide fosifeti iyọ disodium (iyọ disodium NADP)?
Nicotinamide adenine dinucleotide fosifeti (NADP +) jẹ cofactor ti a lo ninu awọn aati aati. β-Nicotinamide adenine dinucleotide fosifeti iyo ni iyọ iyọ ti NADP +, o jẹ coenzyme ti o ṣe pataki fun wiji ọti-lile ti glukosi ati irẹwẹsi atẹgun ti awọn nkan miiran. Ati pe o waye ni ibigbogbo ninu awọ ara laaye, paapaa ninu ẹdọ.
Nicotinamide adenine dinucleotide fosifeti (NADP) ati NADPH ṣe idapo redox. Iwọn NADPH / NADP ṣe ilana agbara iṣipopada iṣan, pataki idahun anaerobic, nitorina ni ipa lori idahun ti ase ijẹ-ara ninu ara. Awọn apẹẹrẹ jẹ eepo ati iṣelọpọ acid aye. NADP tun jẹ bata coenzyme ni ọpọlọpọ awọn eto cytochrome P450 ati awọn eto ifesi oxidase / reductase bii eto thioredoxin reductase / thioredoxin.
NADPH n pese idinku awọn deede fun awọn aati biosynthetic ati pese awọn ipa ipa-ọna lati yago fun majele ti awọn ẹya atẹgun ifamọra (ROS), nitorinaa tun ṣe atunṣe glutathione (GSH). O tun nlo ninu awọn ipa ọna anabolic bii idapọmọra idapọmọra ati ọra acids itẹsiwaju.
Ni afikun, eto NADPH tun jẹ iduro fun ṣiṣẹda awọn ipilẹṣẹ ọfẹ ni awọn sẹẹli ajesara nipasẹ NADPH oxidase. Wọn lo awọn ipilẹṣẹ ọfẹ yii lati pa awọn oniro-arun run ni ilana ti a pe ni fifa atẹgun. O jẹ idinku deede ti orisun aromatiki cytochrome P450 hydroxylated hydroxylated, awọn sitẹriọdu, ọti ati awọn oogun.
ohun elo ti dis-Nicotinamide adenine dinucleotide fosifeti iyọ disodium
Nicotinamide adenine dinucleotide fosifeti (NADP) ati NADPH ṣe idapo redox. NADP / NADPH jẹ coenzyme kan ti o ṣe atilẹyin awọn atunṣe redox nipasẹ gbigbe ti awọn elekitironi ni ọpọlọpọ awọn ohun elo, pataki awọn ifura anaerobic bii eepo ati iṣelọpọ acid. NADP / NADPH jẹ tọkọtaya coenzyme ni ọpọlọpọ awọn eto cytochrome P450 ati awọn eto ifisi ohun elo oxidase / reductase, bii eto thioredoxin reductase / thioredoxin.
Awọn ensaemusi miiran ti o lo NADP bi coenzyme kan ni: Ọra dehydrogenase: NADP ti o gbẹkẹle; ADAM Aromatic: igbẹkẹle NADP; Ferredoxin-NADP reductase; Dehydrogenase L-Fucose; Gabase; Itumọ gbigbe uridyl Galactose-1-fosifeti; Glukosi glukosi; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP kan pato; Isocitric dehydrogenase; Awọn enzymu Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase ati Succinic semialdehyde dehydrogenase.
Reference:
- Hashida SN, Kawai-Yamada M. Inter-Organelle NAD iṣọn-alọ ọkan Nkan ina Idahun Imọlẹ NADP ni Awọn Eweko. Iwaju Ohun ọgbin Sci. 2019 Oṣu Keje 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
- Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Ẹwẹ toje ti iṣan jẹ NAD + ati NADP + glycohydrolase pẹlu iyasọtọ awọn ohun-ini enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Oṣu Kẹjọ 28. PMID: 30593509. PMCID: PMC6398120.
- Liang J, Huang H, Wang S. kaakiri, Itankalẹ, Ẹrọ imọ-ẹrọ Catalytic, ati Awọn iṣẹ-iṣe ti ẹkọ-ara ti Flavin-based Electron-Bifurcating NADH-Dependering Ferredoxin idinku: NADP + Oxidoreductase. Microbiol iwaju. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
- Kawai S, Murata K. "Ẹya ati iṣẹ ti NAD kinase ati NADP phosphatase: awọn enzymu pataki ti o ṣe atunṣe iṣiro intracellular ti NAD (H) ati NADP (H)". Bioscience, Biotechnology, ati Biochemistry. 72 (4): 919-30. ṣe: 10.1271 / bbb.70738. PMID 18391451.
- Hanukoglu I. “Itoju ti Awọn atọkun Enzymu-Coenzyme ni FAD ati NADP Binding Adrenodoxin Reductase-A Enzyme Ubiquitous”. Iwe akosile ti Itankalẹ Molikula. 85 (5-6): 205–218. Bibcode: 2017JMolE..85..205H. ṣe: 10.1007 / s00239-017-9821-9.PMID 29177972.
