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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) jẹ agonist olutayo-peroxisome endogenous-ti mu ṣiṣẹ alpha (PPAR-alpha) ṣiṣẹ. O ti wa ni kan …… ..


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Oleoylethanolamide (OEA) (111-58-0) Awọn alaye ni pato

ọja orukọ Oleoylethanolamide (OEA)
Orukọ Kemikali n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
molikula agbekalẹ C20H39NO2
molikula iwuwo 325.5 g / mol
Ibi Monoisotopic 325.537 g · mol-1
Ofin Melting 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Boiling Point 496.4 ± 38.0 ° C (Asọtẹlẹ)
iwuwo 0.915 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ White
Storage iwa afẹfẹ -20 ° C
Solubility ni ethanol ati DMSO Soluble
ohun elo Phamaceutical aaye; awọn ifiwepe;

Kini Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) jẹ agonist olutayo-peroxisome oni-nọmba ti mu ṣiṣẹ dapọ (PPAR-alpha) agonist. O jẹ adaṣe glycolamide lipid pẹlu ẹda ti ọpọlọpọ awọn ohun-ini homeostasis alailẹgbẹ bii iṣakoso ifẹkufẹ, iṣẹ iṣako-iredodo, iwuri ti lipolysis ati idapọ acid acid. Oleoylethanolamide ni a le gba bi homonu ti ọna ti ọpọlọ inu. Oatmeal, eso, ati koko lulú ni awọn orisun ounjẹ ti o jẹ pataki ti Oleoylethanolamide ninu awọn ounjẹ. Sibẹsibẹ, iye Oleoylethanolamide ti a rii ninu awọn ounjẹ wọnyi kere (kere ju 2 µg / g).

Gẹgẹbi alabọde ti nṣiṣe lọwọ biologically, oleylethanolamide (OEA) ni iṣelọpọ ninu iṣan ati awọn ara miiran, ati pe o ṣe alabapin ninu ilana imudọgba imudara agbara mammalian, ṣe ilana gbigbemi ounjẹ ati ijẹ-ara ti iṣan, gẹgẹbi o le ṣe ilana ounjẹ Vertebrate ati iwuwo ara. Oleoylethanolamide jẹ eepo acid ethanolamide (FAE), afọwọṣe afọwọṣe ti endocannabinoid arachidonic acid ethanolamide (anandamide), ati antagonist iṣẹ ti anandamide. O tọ lati ṣe akiyesi pe Oleoylethanolamide yatọ si anandamide, o jẹ ominira ti olugba cannabinoid, ati ṣiṣe awọn iṣẹ ti isedale rẹ nipasẹ awọn ipa-ọna miiran, nṣakoso iṣẹ PPAR-α lati mu lipolysis ṣiṣẹ. Oleoylethanolamide jẹ agbara ati ailewu egboogi-isanraju iwuwo ti rọpo CB1 antagonism.

Awọn ijinlẹ iṣaaju ti fihan pe Oleoylethanolamide tun jẹ ẹya egboogi-iredodo ati aporo antioxidant ti o ṣe awọn ipa neuroprotective ninu ọti. Isakoso ijade ti Oleoylethanolamide le ṣe idiwọ ọpọlọ TLR4 ti o pọ si awọn iṣedede proinflammatory cascades, nitorinaa idinku itusilẹ awọn cytokines proinflammatory ati chemokines, oxidative ati nitrosative wahala, ati nikẹhin ṣe idilọwọ awọn bibajẹ aifọkanbalẹ ni kotesi iwaju iwaju ti awọn rodents.

Kini iṣẹ Oleoylethanolamide (OEA) ṣiṣẹ?

Ninu eniyan ti o ni isanraju, OEA le ṣatunṣe agbara homeostasis ati yanilenu nipataki nipasẹ ṣiṣiṣẹpọ ti awọn olugba pupọ pẹlu proximal proliferator-activ receptor-α (PPAR-α), olugba-amuṣiṣẹpọ G-protein 119 (GPR119) ati olugba trensient olulu cation ikanni subfamily V (TRPV1). Lootọ, OEA mu awọn olugba wọnyi ṣiṣẹ ati idaduro idaduro ounjẹ, dinku iwọn ounjẹ, dinku awọn arin laarin ounjẹ ati nipari ṣe iṣatunṣe iwuwo ara.

Pẹlupẹlu, diẹ ninu awọn ẹkọ iwadii fihan pe OEA tun ṣe ifasilẹ ikosile ti IL-6, interleukin-8 (IL-8), molikula adhesion molecule-1 (ICAM-1) ati iṣọn sẹẹli adhesion cell-1 (VCAM-1) ni TNF -a ṣe fa iredodo inu awọn sẹẹli ara isan ẹyin endothelial nipasẹ ṣiṣe ti awọn olugba igbin. OEA tun daabobo ipa ọna iparun kappa-B (NF-kB) ninu ara. Ninu iwadi YT et al, OEA (50 µmol / L) ṣe idiwọ ifilọlẹ TNF-α indumare VCAM-1 ni HUVEC.

Awọn anfani ti Oleoylethanolamide (OEA)

Gẹgẹbi inhibitor ceramidase, agonist ti igbẹhin ti olugba GPR119, Oleoylethanolamide munadoko si awọn aarun neurodegenerative, anti-atherosclerosis, apoptosis, iderun irora, imudara iṣọn-ọfun, ati awọn sẹẹli lori awọn sẹẹli islet β. Aabo ati awọn arun ti iṣelọpọ miiran ni ipa aabo ti o dara. Ni afikun, o le dinku ọra ara nipa ṣiṣakoso ounjẹ, iwuwo iṣakoso, ati aṣeyọri pipadanu iwuwo. Oleoylethanolamide tun ni agbara lati dinku iredodo ati awọn ipele idaabobo kekere.

Awọn ipawo ti Oleoylethanolamide (OEA)

  • Phamaceutical aaye Awọn ounjẹ ounjẹ
  • Gaetani S, Oveisi F, Piomelli D (2003). “Awoṣe ilana ounjẹ ninu eku nipasẹ olulaja ọra alagidi irorun oleoylethanolamine”. Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). “Ilana gbigbemi ounje nipasẹ oleoylethanolamine”. Ẹjẹ. Mol. Igbesi aye Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). “Ilọsi postprandial ti koriya oleoylethanolamine ni iṣan kekere ti iṣan ti Burmese Python (Python molurus)”. Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Oṣu Kẹsan ọdun 2008). “Ipa ti endocannabinoids ati awọn analo wọn ni isanraju ati rudurudu ijẹun”. Je Disord Disight. 13 (3): e42-8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: awọn ipa lori awọn atagba hypothalamic ati awọn ikun ti o nṣakoso gbigbemi ounjẹ. Neuropharmacology. (2011)

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