Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020

Oleoylethanolamide (OEA) jẹ apaniyan peroxisome prooporator-ṣiṣẹ olugba olugba alpha (PPAR-alpha) agonist. O jẹ …… ..

 


ipo: Ni Ifilelẹ Production
Apapọ: 25kg / Ilu

 

Oleoylethanolamide (OEA) (111-58-0) fidio

Oleoylethanolamide (OEA) (111-58-0) Awọn alaye ni pato

 

ọja orukọ Oleoylethanolamide (OEA) lulú
Orukọ Kemikali n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
molikula agbekalẹ C20H39NO2
molikula iwuwo 325.5 g / mol
Ibi Monoisotopic 325.537 g · mol-1
Ofin Melting 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
Boiling Point 496.4 ± 38.0 ° C (Asọtẹlẹ)
iwuwo 0.915 ± 0.06 g / cm3 (Sọtẹlẹ)
Awọ Funfun funfun
Storage iwa afẹfẹ -20 ° C
Solubility ni ethanol ati DMSO Soluble
ohun elo Phamaceutical aaye; awọn ifiwepe;

 

Akopọ

Oleoylethanolamide (OEA) tabi N-Oleoylethanolamide (OEA) jẹ molikula ti a ṣe sinu ara, nigbagbogbo a rii ninu awọn ifun. Ẹri ti n pọ si ni imọran pe OEA le ṣe bi ifosiwewe neuroprotective endogenous ati kopa ninu iṣakoso ti awọn ihuwasi ti o ni ibatan ẹsan. Pẹlupẹlu, o ti ṣe apejuwe bi oluṣe lilu ti o lọ kuro ti o dinku gbigbemi ounjẹ ati ere iwuwo ara.

 

Kini Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) jẹ agonist olugba olugba olugba proliferator peroxisome ti o ni agbara pupọ (PPAR-alpha). O jẹ ọra glycolamide ti o nwaye nipa ti ara pẹlu ọpọlọpọ awọn ohun-ini alailẹgbẹ alailẹgbẹ bii iṣakoso aito, iṣẹ iredodo-ara, iwuri ti lipolysis ati ifoyina ọra. Oleoylethanolamide ni a le kà si homonu ti ipo iṣan ọpọlọ. Oatmeal, eso, ati koko lulú jẹ awọn orisun awọn ounjẹ pataki ti Oleoylethanolamide ninu awọn ounjẹ. Sibẹsibẹ, iye Oleoylethanolamide ti a rii ninu awọn ounjẹ wọnyi jẹ kekere (o kere ju 2 µg / g).

Gẹgẹbi alabọde ti nṣiṣe lọwọ biologically, oleylethanolamide (OEA) ni iṣelọpọ ninu iṣan ati awọn ara miiran, ati pe o ṣe alabapin ninu ilana imudọgba imudara agbara mammalian, ṣe ilana gbigbemi ounjẹ ati ijẹ-ara ti iṣan, gẹgẹbi o le ṣe ilana ounjẹ Vertebrate ati iwuwo ara. Oleoylethanolamide jẹ eepo acid ethanolamide (FAE), afọwọṣe afọwọṣe ti endocannabinoid arachidonic acid ethanolamide (anandamide), ati antagonist iṣẹ ti anandamide. O tọ lati ṣe akiyesi pe Oleoylethanolamide yatọ si anandamide, o jẹ ominira ti olugba cannabinoid, ati ṣiṣe awọn iṣẹ ti isedale rẹ nipasẹ awọn ipa-ọna miiran, nṣakoso iṣẹ PPAR-α lati mu lipolysis ṣiṣẹ. Oleoylethanolamide jẹ agbara ati ailewu egboogi-isanraju iwuwo ti rọpo CB1 antagonism.

Awọn ijinlẹ iṣaaju ti fihan pe Oleoylethanolamide tun jẹ ẹya egboogi-iredodo ati aporo antioxidant ti o ṣe awọn ipa neuroprotective ninu ọti. Isakoso ijade ti Oleoylethanolamide le ṣe idiwọ ọpọlọ TLR4 ti o pọ si awọn iṣedede proinflammatory cascades, nitorinaa idinku itusilẹ awọn cytokines proinflammatory ati chemokines, oxidative ati nitrosative wahala, ati nikẹhin ṣe idilọwọ awọn bibajẹ aifọkanbalẹ ni kotesi iwaju iwaju ti awọn rodents.

 

Awọn orisun ti Oleoylethanolamide (OEA)

Orisun meji lo wa ti gbigba Oleoylethanolamide (OEA), ọkan jẹ lati awọn ohun alumọni, ati ekeji jẹ nipasẹ iṣetọ mimọ ni lab.

Achyranthes Aspera, ilu abinibi si India, China ati ọpọlọpọ awọn orilẹ-ede miiran ti Esia, ni a sọ pe o ni Oleoylethanolamide OEA. Iṣoro ti Oleoylethanolamide ti adayeba-pe ni pe iṣedede ipin nikan ni o wa, 15: 1 jẹ apẹrẹ olokiki, ati pe kii ṣe agbara bi awọn alabara tabi awọn aṣelọpọ afikun ṣereti. Nitoribẹẹ, o le ga julọ, ṣugbọn idiyele naa yoo gaju pupọ, nitorinaa ko wulo lati ṣe iṣelọpọ Oleoylethanolamide adayeba ni OEA ni olopobobo.

Orisun akọkọ ti Oleoylethanolamide jẹ adapo lati oleic acid, yoo ṣiṣẹ bi iṣaaju ti N-oleoyl-phosphatidylethanolamine, eyiti o jẹ fifọ nipasẹ N-acyl-phosphatidylethanolamine-yiyan phospholipase D (PLD) lati tu OleoylethanAA silẹ.

Oleoylethanolamide jẹ iṣelọpọ agbara adayeba ti oleic acid. Nitorinaa, awọn ounjẹ ṣe mimu oleic acid jẹ orisun taara ti OEA.

 

Bawo ni ti Oleoylethanolamide (OEA) ṣiṣẹ?

Ninu eniyan ti o ni isanraju, OEA le ṣatunṣe agbara homeostasis ati yanilenu nipataki nipasẹ ṣiṣiṣẹpọ ti awọn olugba pupọ pẹlu proximal proliferator-activ receptor-α (PPAR-α), olugba-amuṣiṣẹpọ G-protein 119 (GPR119) ati olugba trensient olulu cation ikanni subfamily V (TRPV1). Lootọ, OEA mu awọn olugba wọnyi ṣiṣẹ ati idaduro idaduro ounjẹ, dinku iwọn ounjẹ, dinku awọn arin laarin ounjẹ ati nipari ṣe iṣatunṣe iwuwo ara.

Pẹlupẹlu, diẹ ninu awọn iwadii adanwo fihan pe OEA tun n tẹ ọrọ IL-6 mọlẹ, interleukin-8 (IL-8), molulu-adhesion molulu intercellular ati molikula adhesion alagbeka iṣan-1 (VCAM-1) ni TNF -α iredodo ti a fa sinu iṣan ara iṣan ara awọn ẹyin endothelial nipasẹ ṣiṣiṣẹ ti awọn olugba iredodo. OEA tun ṣe idiwọ ipa ọna iparun kapa-B (NF-kB) ninu ara. Ninu iwadi YT et al, OEA (1 µmol / L) ṣe idiwọ ọrọ ikasi VNAM-1 ti TNF-α ni HUVEC.

 

Awọn anfani ti Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) lulú dara lati padanu iwuwo bi olutọju ifẹkufẹ ati ṣe atilẹyin awọn ipele idaabobo awọ ni awọn agbalagba.

 

Oleoylethanolamide (OEA) bi afunisora ​​fun

Ibẹwẹ itara ati nitorinaa idinku gbigbemi ounjẹ jẹ ọna ti o munadoko lati ṣakoso iwọntunwọnsi agbara ati iwuwo ara. Niwọn igbati iyọkujẹ jẹ aaye iṣakoso idari pataki fun agbara (ounjẹ) mimu, mimu ifẹkufẹ jẹ pataki ni ṣiṣakoso iwuwo ara ti ilera, ni pataki nigbati a ba darapọ mọ awọn aṣayan igbesi aye mimọ ti ilera ti o ni ifojusi si gbigbemi ounje to tọ, afikun ijẹẹmu, ati adaṣe.

Afikun Oleoylethanolamide ṣe iranlọwọ lati ṣatunṣe iṣelọpọ ti iṣan, ṣe iranlọwọ lati ṣakoso ebi nipa fifiranṣẹ awọn ifiranṣẹ irekọja si ọpọlọ ati pe o ti han lati ṣe iranlọwọ lati dinku mejeeji triglyceride ati awọn ipele idaabobo awọ.

 

Oleoylethanolamide fun Isakoso ọra Ara

OEA jẹ awọn ọna ẹrọ ailewu ailewu ti n ṣakoso ifẹkufẹ ati inawo inawo.

Awọn ipa ti OEA ni a kọkọ kọwe nitori pe o pin awọn ibajọra pẹlu kemikali miiran, cannabinoid ti a mọ bi anandamide. Cannabinoids jẹ ibatan si ọgbin Cannabis ọgbin, ati awọn anandamides ti o wa ninu ọgbin (ati marijuana) le mu ki ifẹ eniyan pọ si ipanu nipa fifa esi ifunni. Gẹgẹbi Wikipedia, Oleoylethanolamide jẹ analoamide endocannabinoid anikanamide. Biotilẹjẹpe OEA ni eto kemikali kan ti o jẹ iru si anandamide, awọn ipa rẹ lori jijẹ ati iṣakoso iwuwo yatọ. Ko dabi anandamide, OEA n ṣe ni ominira laisi ipa ọna cannabinoid, nṣakoso iṣẹ PPAR-α lati ṣe okunkun lipolysis.

 

Oleoylethanolamide ti ara

Gbogbo eniyan n wa ilera nipasẹ iṣelọpọ ara ni ibi-ere-idaraya. OEA jẹ diẹ si olokiki si awọn bodybuilders. Ni awọn aaye afikun awọn afikun ara, TTA (tetradecylthioacetic acid) ni a maa n lo synergistically pẹlu oleoylethanolamide (OEA), mejeeji ti tun ṣe iranlọwọ lati sun sanra ati dinku ebi. TTA tun le jẹ adehun pupọ laarin awọn afikun egboogi-ọra, nitori o han lati sun ọra olominira ti idaraya; Awọn abajade alakoko ni imọran pe ara rọrun lati han “yọ” ọra kuro ninu ara rẹ dipo nilo lati ni ki o sunna pẹlu iṣẹ ṣiṣe ti ara.

Oleoylethanolamide (OEA) dinku triglycerides ati idaabobo awọ, ati pe, ni idapo pẹlu antagonist cannabinoid, ṣe idiwọ iwuwo ara ati imudara dyslipidaemia ninu awọn awoṣe ẹranko ti isanraju.

Ni afikun, iṣakoso eto ṣiṣe ti oleoylethanolamide ni a ti ri lati ṣe iyipada glucose homeostasis, bi idasilẹ hisulini mejeeji ati ifihan agbara hisulini ninu awọn hepatocytes ati adipocytes.

Diẹ ninu atunyẹwo fihan pe afikun oleoylethanolamide ni awọn ipa rere lori aibalẹ, ati pe awọn itọpa diẹ sii ati ẹri ni a nilo lati ṣe atilẹyin.

 

Bi o ṣe le lo Oleoylethanolamide OEA

 

Oawọn ipa ẹgbẹ leoylethanolamide

Oleoylethanolamide OEA jẹ tuntun tuntun si ọja afikun, ati pe ko si awọn ikolu ti ko dara to ti royin. Isakoso Ounje ati Oògùn AMẸRIKA (FDA) ko ni awọn ifiyesi nipa aabo OEA. Ni igbesi aye ojoojumọ, oleoylethanolamide jẹ yiyan iwuwo pipadanu iwuwo, eyiti a lo lati ṣe ayẹwo iye ti catabolism ninu iṣan-ọpọlọ, iranlọwọ lati dinku ọra laisi eyikeyi awọn ipa aibikita.

 

Oleoylethanolamide doseji

Ko si iwọn lilo niyanju ni gbangba fun oleoylethanolamide niwon awọn afikun oleoylethanolamide ko tun jẹ olokiki ati ni ipele ibẹrẹ rẹ. RiduZone jẹ lulú OEA akọkọ ti iyasọtọ ni ọdun 2015.

Iwọn lilo oleoylethanolamide ti a ṣe iṣeduro jẹ kapusulu 200mg kan nigbati o ba mu laisi apapọ

Iwadi daba pe o tun le dinku tabi mu iwọn lilo ojoojumọ ni ibamu si iwuwo ara rẹ.

100mg fun eniyan 150lb kan

145mg fun eniyan 200lb kan

180mg fun eniyan 250lb kan

 

Ohun elo ti Oleoylethanolamide (OEA)

Oleoylethanolamide lulú ti lo ni afikun itọju Ilera, ti a ṣe sinu kapusulu lile tabi tabulẹti fun Isonu iwuwo.

 

Reference:

  • Gaetani S, Oveisi F, Piomelli D (2003). “Imudarapọ ti apẹẹrẹ ounjẹ ni eku nipasẹ alabode ọra anorexic oleoylethanolamine”. Neuropsychopharmacology. 28 (7): 1311-6. ṣe: 10.1038 / sj.npp.1300166. PMID 12700681.

 

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). “Ilana ti gbigbe ounjẹ nipasẹ oleoylethanolamine”. Sẹẹli. Mol. Igbesi aye Sci. 62 (6): 708–16. ṣe: 10.1007 / s00018-004-4494-0. PMID 15770421.

 

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). “Alekun ifiweranṣẹ ti koriya oleoylethanolamine ni ifun kekere ti Python Burmese (Python molurus)”. Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. ṣe: 10.1152 / ajpregu.00664.2005. PMID 16373434.

 

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Oṣu Kẹsan 2008). “Ipa ti endocannabinoids ati awọn analogues wọn ninu isanraju ati awọn rudurudu jijẹ”. Je Ẹjẹ iwuwo. 13 (3): e42-8. PMID 19011363.

 

  • Serrano A, et al. Oleoylethanolamide: awọn ipa lori awọn atagba hypothalamic ati awọn ikun ti o nṣakoso gbigbemi ounjẹ. Neuropharmacology. (2011)