Nicotinamide adenine dinucleotide (53-84-9) fidio
Nicotinamide adenine dinucleotide (53-84-9) Sawọn ilana
| ọja orukọ | Nicotinamide adenine dinucleotide (NAD +) |
| Orukọ Kemikali | Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
| CAS Number | 53-84-9 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| molikula agbekalẹ | C21H27N7O14P2 |
| molikula iwuwo | 663.4 g / mol |
| Ibi Monoisotopic | 663.109123 g / mol |
| Ofin Melting | 160 ° C (320 ° F; 433 K) |
| Awọ | White |
| Storage iwa afẹfẹ | 2-8 ° C |
| solubility | H2O: 50 mg / milimita |
| ohun elo | Ounje ilera, ikunra, ifunni ifunni |
ohun ti o jẹ Nicotinamide adenine dinucleotide(NAD +)?
Nicotinamide adenine dinucleotide (NAD) jẹ cofactor kan ti o ṣe iranlọwọ iṣelọpọ ti a rii ni gbogbo awọn sẹẹli ngbe. O wa ni awọn ọna meji, oxidized (NAD +) ati dinku (NADH).
Coenzyme NAD +, fọọmu oxidized ti NAD, ni akọkọ ṣe awari ni ọdun 1906 nipasẹ awọn onimọ-biochemist ti ilu Britain Arthur Harden ati William John Young. NAD + jẹ iṣelọpọ nipasẹ awọn ipa ọna gbigbepọ meji, eyiti o le ṣe lati ọna opopona de novo amino acid, tabi le ṣe iṣelọpọ nipasẹ atunlo awọn ohun elo ti iṣaju iṣaaju (bii nicotinamide) pada si ọna igbala ti NAD +. O jẹ ẹya iparun pyridine pataki ati ṣiṣẹ bi cofactor pataki ati aropo fun ọpọlọpọ awọn ilana ilana sẹẹli bọtini ti o ni irawọ-ara oxidative ati iṣelọpọ ATP, atunṣe DNA, ilana ilana eegun ti ikosile pupọ, ami ifihan kalsia iṣan ati iṣẹ Immunological.
NAD + jẹ ohun elo itẹwọgba gbigba elekitironi ni ifoyina nipa ẹda. O gba awọn elekitiro lati awọn ohun alumọni miiran ati dinku. O tun ṣe bi coenzyme ti itankale hydride ati aropo ti o jẹ NAD (+) polymerase, ati ṣe apẹrẹ coenzyme redox pẹlu dinku β-nicotinamide adenine dinucleotide (NADH). NAD (R) jẹ ribosylation ADP-ribose ninu ADP-A. O tun jẹ ipilẹṣẹ si cyclic ADP-ribose (ADP-ribosyl cyclase).
Gẹgẹbi ifasita ninu iṣelọpọ ara, NAD (R) tun ṣe ipa ninu awọn aati gbigbe gbigbe adenosine diphosphate (ADP) -ribose ti o kan diadenylate (ADP-ribose) polymerase ati ọpọlọpọ awọn ilana enzymu miiran. O le ni aabo fun NAD lati ṣe idiwọ tabi dinku suga, akàn ati awọn aisan miiran ti o ni ibatan ọjọ-ori. Pẹlupẹlu, awọn boosters NAD + le ṣiṣẹ synergistically pẹlu awọn afikun bi resveratrol lati ṣe iranlọwọ lati sọji mitochondria diju ati ja awọn arun ti ogbo.
Nicotinamide adenine dinucleotide(NAD +) awọn anfani
Gẹgẹbi oxidant ti o munadoko, Nicotinamide adenine dinucleotide fihan pe diẹ ninu awọn anfani to dara ninu awọn iṣẹ eniyan.
♦ Je ki iṣẹ ṣiṣe cellular rẹ dara julọ,
♦ Mu agbara rẹ pọ si nipa ti ara;
♦ Mu iṣẹ ọpọlọ dara si, idojukọ ati iranti;
♦ Boost your metabolism;
♦ Mu oorun sun;
Activity Ṣe alekun iṣẹ sirtuin agbaye;
♦ Mu ilọsiwaju antioxidant ṣiṣẹ;
Inflammation Din igbona silẹ;
Balance Iwontunws.funfun, iṣesi, iranran ati igbọran;
Nicotinamide adenine dinucleotid tun jẹ ibi-afẹde taara ti isoniazid ti oogun, eyiti a lo ninu itọju ti ikọ-ara, ikolu ti o ṣẹlẹ nipasẹ iko-ara Mycobacterium. Ninu idanwo kan, awọn eku ti a fun NAD fun ọsẹ kan ti ni ilọsiwaju ibaraẹnisọrọ ibaraẹnisọrọ-mitochrondrial.
Ni afikun, Nicotinamide adenine dinucleotide (NAD +) tun ni idena ati itọju ti bulọki ọkan, iṣẹ ẹṣẹ oju-iwe ati ọpọlọ ariyanjiyan, egboogi-nicotinamide le ṣe alekun oṣuwọn ọkan pupọ ati titọ atriove ntricular ti o fa nipasẹ verapamil.
Nicotinamide adenine dinucleotide(NAD +) ohun elo:
- Ṣiṣe ayẹwo awọn atunlo awọn ohun elo aise, awọn adanwo iwadi imọ-jinlẹ.
- Ounje ilera, ikunra, ifunni ifunni
- API iṣelọpọ
Die Nicotinamide adenine dinucleotide(NAD +) iwadii
Awọn enzymu ti o ṣe ati lo NAD + ati NADH jẹ pataki ni oogun oogun mejeeji ati iwadi sinu awọn itọju ọjọ iwaju fun aisan. Coenzyme NAD + kii ṣe funrararẹ lo lọwọlọwọ fun itọju fun eyikeyi aisan. Sibẹsibẹ, o n kawe fun lilo agbara rẹ ni itọju ailera ti awọn aarun neurodegenerative gẹgẹbi aisan Alzheimer atiParkinson.
Reference:
- Belenky P, Bogan KL, Brenner C (2007). "Iṣeduro NAD + ni ilera ati aisan" (PDF). Awọn aṣa Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Gbepamo lati ipilẹṣẹ (PDF) ni Oṣu Keje 4, Ọdun 2009. Ti gba pada ni Oṣu kejila 23 2007.
- Todisco S, Agrimi G, Castegna A, Palmieri F (2006). “Idanimọ ti transporter NAD + mitochondrial ni Saccharomyces cerevisiae”. J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
- Lin SJ, Guarente L (Oṣu Kẹrin 2003). "Nicotinamide adenine dinucleotide, olutọju iṣelọpọ ti transcription, gigun ati aisan". Curr. Opin. Ẹrọ Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
- Williamson DH, Lund P, Krebs HA (1967). “Ipo redox ti nicotinamide-adenine dinucleotide ọfẹ ninu cytoplasm ati mitochondria ti ẹdọ eku”. Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- Foster JW, Moat AG (1 Oṣu Kẹta Ọjọ 1980). “Nicotinamide adenine dinucleotide biosynthesis ati pyridine nucleotide ọmọ ti iṣelọpọ ninu awọn eto makirobia”. Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
- Faranse SW. Binging ọti ọti onibaje mu ẹdọ ati awọn ara miiran jẹ nipa idinku awọn ipele NAD⁺ ti o nilo fun iṣẹ deacetylase sirtuin. Exp Mol Pathol. 2016 Oṣu Kẹwa; 100 (2): 303-6. ṣe: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
- Kane AE, Sinclair DA. Sirtuins ati NAD + ni Idagbasoke ati Itọju ti Ikun-ọkan ati Awọn Arun inu ọkan ati ẹjẹ. Resc 2018 Oṣu Kẹsan 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.
