Urolithin A.

April 8, 2021

Urolithin A ti ṣe afihan lati mu mitophagy mu ati mu ilera iṣan dara ni awọn ẹranko atijọ ati ni awọn awoṣe ti iṣaaju ti ogbologbo. Nibayi, o tun ti han lati kọja idena ọpọlọ ọpọlọ, ati pe o le ni awọn ipa ti ko ni aabo nipa Arun Alzheimer.

Urolithin A (1143-70-0) fidio

Urolithin A (1143-70-0)ni pato

ọja orukọ Urolithin A lulú
Orukọ Kemikali 3,8-dihydroxy-6H-benzo [c] chromen-6-ọkan;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-ọkan;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-ọkan;

6H-Dibenzo [b, d] pyran-6-ọkan, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number 1143-70-0
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
molikula Fagbalagba C13H8O4
molikula Wmẹjọ 228.2 g / mol
Ibi Monoisotopic 228.042259 g / mol
yo ojuami 340-345 ° C
farabale ojuami  527.9 ± 43.0 ° C (Asọtẹlẹ)
Oju filaṣi 214.2ºC
Idaji Ida-Omi Urolithin A wa ninu ito titi di wakati 48 lẹhin lilo oje pomegranate.
Awọ Funfun si alagara
Solubility  DMSO: 20 mg / mL, ko o
Sdidiṣi Tti otutu  2-8 ° C
Application Ti a lo bi afikun ounjẹ ati ọja alatako, le ṣee lo lati dinku iredodo ati ja akàn;

 

Reference:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Apejọ ti iṣelọpọ ti Ellagitannins: Awọn Imuwa fun Ilera, ati Awọn Iwadi Iwadi fun Awọn ounjẹ Iṣẹ-ṣiṣe Alailẹgbẹ". Awọn atunyẹwo Lominu ni Imọ Ounje ati Ounjẹ. 54 (12): 1584–1598. ṣe: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A n fa mitophagy mu ki o fa gigun igbesi aye ni C. elegans ati mu iṣẹ iṣan pọ si ninu awọn eku. Nat. Med. 22, 879–888 (2016).

[3] "FDA GRAS ṣe akiyesi GRN NỌ 791: urolithin A". US Ounje ati Oogun ipinfunni. 20 Oṣù Kejìlá 2018. Ti gba pada ni 25 August 2020.

[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). “Urolithin A ti a nṣakoso ẹnu jẹ ailewu ati ṣe atunṣe iṣan ati awọn oniṣowo bioococ mitochondrial ni agbalagba”. Innovation in Ogbo. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). “Ayẹwo aabo ti urolithin A, ijẹẹmu ti iṣelọpọ nipasẹ iṣan eniyan microbiota lori gbigbe ti ijẹẹmu ti awọn ellagitannins ti ọgbin ati ellagic acid”. Ounjẹ ati Kemikali Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.